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Cardiac Surgery

Cardiac Surgery

DARTS: Dissected Aorta Repair Through Stent Implantation: A Postmarket Study

The purpose of the DARTS registry is to collect and store medical information, imaging scans and other information from individuals with aortic dissections treated with the AMDS. Information from patients in this registry will be used for medical research to better understand aortic dissections and how the AMDS is improving the care of the patients. Scientists and doctors studying and treating aortic dissections want to learn more about how the disease affects patients and the mechanisms by which the AMDS is improving their care.

  • Condition: Aortic Dissection
  • WebsiteNCT03894033
  • Sponsor: Ascyrus Medical LLC.
  • Location: Saint John Regional Hospital
  • Horizon Principal Investigator: Dr. Zlatko Pozeg
  • To participate, call the research coordinator at: 506-648-7360 and refer to study file #100524

NEWTON-CABG: A randomized trial of evolocumab on saphenous vein graft patency following coronary artery bypass surgery

The purpose of this study is to test whether participants who receive evolocumab, in addition to their normal statin therapy, will help to reduce the proportion of vein grafts that become blocked after CABG surgery, as compared to participants who receive normal statin therapy alone.

  • Condition: Coronary Artery Bypass Graft Surgery, Atherosclerosis, Vein Occlusion
  • WebsiteNCT03900026
  • Sponsor: Unity Health Toronto
  • Location: Saint John Regional Hospital
  • Horizon Principal Investigator: Dr. Craig Brown
  • To participate, call the research coordinator at: 506-648-7360 and refer to study file #100588

REVERSE-IT: A Phase 3, Multicenter, Open-Label, Single-Arm Study of Bentracimab (PB2452) in Ticagrelor-Treated Patients With Uncontrolled Major or Life-Threatening Bleeding or Requiring Urgent Surgery or Invasive Procedure

This is a multi-center, open-label, prospective single-arm study of reversal of the antiplatelet effects of ticagrelor with bentracimab (PB2452) in patients who present with uncontrolled major or life-threatening bleeding or who require urgent surgery or invasive procedure.

  • Condition: Hemorrhage, Urgent Surgery, Invasive Procedure
  • WebsiteNCT04286438
  • Sponsor: PhaseBio Pharmaceuticals Inc.
  • Location: Saint John Regional Hospital
  • Horizon Principal Investigator: Dr. Craig Brown
  • To participate, call the research coordinator at: 506-648-7360 and refer to study file #101172

START: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Effect of RBT-1 on Preconditioning Response Biomarkers in Subjects Undergoing Coronary Artery Bypass Graft (CABG) and/or Cardiac Valve Surgery

RBT-1, an investigational new drug, is being developed to prevent damage to the kidney that occurs as a complication of heart surgery. The main purpose of the study is to see whether RBT-1 can increase proteins in the body that are associated with protecting organs from injury.

  • Condition: Heart surgery, anemia
  • Website:  NCT04564833
  • Sponsor: Renibus Therapeutics, Inc
  • Location: Saint John Regional Hospital
  • Horizon Principal Investigator: Dr. Craig Brown
  • To participate, call the research coordinator at: 506-648-7360 and refer to study file #101277

TITAN SvS: Treatment In Thoracic Aortic Aneurysm: Surgery versus Surveillance

This study is being done to compare early surgery to monitoring in patients with large aorta of between 5.0 - 5.4 cm. A large aorta may have higher chance of tearing or bursting, and we are trying to find out if performing surgery earlier can help more patients prevent these events. We are trying to determine whether it is better for patients with aortas 5.0-5.4 cm to have surgery before their aorta grows even more, or if they should wait and be monitored.

  • Condition: Ascending Aortic Aneurysm Enlargement
  • WebsiteNCT03536312
  • Sponsor: Ottawa Heart Institute Research Corporation
  • Location: Saint John Regional Hospital
  • Horizon Principal Investigator: Dr. Zlatko Pozeg
  • To participate, call the research coordinator at: 506-648-7360 and refer to study file #101002

TRICS IV: Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery

The purpose of this study is to compare two different types of transfusion strategies in patients between the ages of 19-65 who are scheduled for heart surgery using the heart-lung machine. The "restrictive" strategy will use a lower hemoglobin level, and the "liberal" strategy will use a higher hemoglobin level for transfusion triggers.

  • Condition: Heart surgery, anemia
  • Website:  NCT04754022
  • Sponsor: Dr. David Mazer, St. Michael's Hospital, Unity Health Toronto, Toronto; Dr. Nadine Shehata, Mount Sinai Hospital, Toronto
  • Location: Saint John Regional Hospital
  • Horizon Principal Investigator: Dr. Craig Brown
  • To participate, call the research coordinator at: 506-648-7360 and refer to study file #101258

VIVA: Transcatheter Aortic Valve Replacement Versus Surgical Aortic Valve Replacement for Treating Elderly Patients with Severe Aortic Stenosis and Small Aortic Annuli: A Prospective Randomized Study

The aim of this study is to compare valve performance (incidence of severe patient-prosthetic mismatch and the incidence of residual valve leaks, termed aortic regurgitation) in patients who will undergo catheter aortic valve replacement versus standard surgery patients. This study will also evaluate clinical events (death, stroke, major or fatal bleeding) in each of the two groups.

  • Condition: Degenerative Aortic Valve Disease, Aortic Stenosis, Aortic Regurgitation
  • Website:  NCT03383445
  • Sponsor: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
  • Location: Saint John Regional Hospital
  • Horizon Principal Investigator: Dr. Craig Brown
  • To participate, call the research coordinator at: 506-648-7360 and refer to study file #100042
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